I am applying this methodology to Knuth's TAOCP. So far so good, as I am actually getting through the book this time, because I am just doing the initial read through. TAOCP always used to stump me when I've tried to go through it before because I normally try to understand everything I read before continuing a book. This way at least I am building up an understanding of what I need to learn to be able to understand the book.
One of the key features of Adler's methods, which he emphasizes in _A Guidebook to Learning_, is to "read and discuss". Those who have access to discussion with other learners or mentors, whether in a work or school environment, I think have a great advantage compared to those learning alone.
In developing the skills of reading, initially one may need to read stuff twice. With skill and practice, one reading may accomplish several kinds of goals at once.