[travisoliphant]

Cython is helpful, but you have to spell out a lot of type-information that is not specifically necessary. You might also try Numba --- easiest way to get it is via Anaconda CE or Wakari. Both at http://continuum.io

[kkuduk]

Here is a pretty nice example how to use Numba and some expectations about the speedup you may get: https://www.wakari.io/nb/travis/numba