[Lazare]

Although I agree in general, PyCharm has recently been adding explicit support for Vagrant and virtualenv in their latest betas, and it works pretty well.

Basically does what you'd hope. I've got Django installed inside a virtualenv inside a linux Vagrant VM, and PyCharm running on the host OS is able to start a Django server, do interactive debugging, autocomplete function names, install new packages to the virtualenv, etc, etc. It's really just like you'd hope, and in my view just as good as PyCharm pointed at a "native" python/django install running on the host OS directly.