[vladms]

Look into cancer survival rates : https://www.cancer.org/research/acs-research-news/people-are... , to quote "Decades of cancer research have provided health care professionals with the tools to treat cancer more effectively, so that cancer in general is becoming less of a death sentence and more of a treatable chronic disease,"

So with the current system, some things work, some things don't work (ex: psychology/Alzheimer). Yes, the system should be improved. No, I am not convinced that "destroying" the current system will result very easily into something better.

We need to discuss actual solutions for the replication crisis. There are even steps towards improving that, like requiring open data for papers, which makes it harder for people to do some of the manipulations that resulted in the replication crisis. I personally would go even further: you should provide complete documentation (tools, notes, data, raw files, etc.), but then there are some people opposing that due to "privacy" (for medical) or "patents" (for industrial stuff).

[adastra22]

What you are implicitly assuming is that the publication and review system matters for that cancer research. Cancer progress, as I understand, is mostly driven by NIH priorities, which are set by governmental review committees. Published work plays a part in that, but it is not the decentralized-review that is typical of other areas of research (e.g. psychology and Alzheimer's).

The peer review system as we know it today has only really existed for less than a century. It is no how science was traditionally done. It was adopted due to some real problems with the old system, so I'm not saying we should go back. But it's not clear either that unpaid peer-review is the ultimate end-state either.

100% agreement on your last paragraph though.