[jefftk]

This is an important question, but because of the danger of trying to do it for real it's not one SecureBio has taken or is likely to take on. Instead we and others in the field have generally tried to work through proxies: is there something that is about as hard while not being dangerous? The closest I can think to testing whether "someone smart but completely untrained / unfamiliar with biology" can cause harm now is ActiveSite's study (https://arxiv.org/abs/2602.16703) which was a null result with models from a year ago. But:

1. The main worry isn't current models, but near-future significantly better ones.

2. There are many actors who are not "completely untrained / unfamiliar with biology". If models get to where they can uplift complete novices that does massively expand the range of threat actors, but even before then risk would be much higher than today.