[attila-lendvai]

> TB is also shockingly infectious

let's keep HN as a place where people usually do at least a cursory research before they state things with such confidence... or inject a few words of doubt to signal that you haven't done the homework.

if you feel the urge to fight this: i lived with someone infected with TB.

e.g. measles is shockingly infectious. TB is not.

[jquery]

A single, untreated person with TB will infect 1.5 to 4 people if public health interventions don’t happen. Measles sits at 12 to 18 people per infected person.

In case anyone was curious. Depending on what your priors were, 1.5 to 4 might be shocking.

[attila-lendvai]

don't forget that untreated TB runs for years, sometimes for many years.

measles heals in weeks (and 99.9% non-malnutrished survives without lasting damage; see France prior to 1983).

[attila-lendvai]

also note the exponential function here... and an exponent of 2 and 12 are very different animals.

[everforward]

Depends heavily on whether we're measuring in practical terms, or in "no medical intervention" terms.

If we're measuring in a vacuum without medicine, then absolutely, the measles is dramatically more infectious.

If we're measuring in the real world where medicine exists, the measles has a safe, cheap and effective vaccine. New case rates dropped 76% between 2000 and 2018 due to extensive vaccination campaigns, and new cases of the measles globally sits a hair below TB right now. The WHO has a plan to eradicate it (and rubella) just like polio.

Meanwhile TB is now the leading cause of infectious death in the world, and the WHO estimates 1 in 4 people globally have either active or latent TB. Despite having similar new case numbers, TB kills 13 people for every 1 person the measles does.

I would describe a disease that 1 in 4 people globally have and is the world's leading cause of death as "shockingly infectious". I doubt it is the most infectious, but I think shockingly infectious is apt.

> i lived with someone infected with TB.

If they were latent, no one would expect you to have contracted TB. Latent TB isn't infectious. If they had active TB, I would personally get tested for latent TB. Not showing symptoms isn't dispositive of contracting TB, it can lay dormant for a long time or forever. I'm not saying you would definitely have contracted it enough, but the odds are high enough and risks serious enough that I'd want it treated before it became active.

[attila-lendvai]

re TB: you think i wouldn't know? and it was found because it was active.

re eradicating measles: the terrain is much more complicated than presented. first, because the vaccine fades away, and without measles spreading in the young population, adults don't get natural reminders, and eventually there can be a big wave without poking everyone. and the disease is much more dangerous for adults. and all this unnecessary trouble for a disease that is not really dangerous when left alone and the population is not malnutrished.

and there's that cancer thing with measles, just to shed some light on the complexity:

MEASLES: Albonico et al found that adults are significantly protected against non-breast cancers — genital, prostate, gastrointestinal, skin, lung, ear-nose-throat, and others — if they contracted measles (odds ratio, OR = 0.45), rubella (OR = 0.38) or chickenpox (OR = 0.62) earlier in life. [Med Hypotheses 1998; 51(4): 315-20]. https://www.ncbi.nlm.nih.gov/m/pubmed/9824838/

MEASLES: Montella et al found that contracting measles in childhood reduces the risk of developing lymphatic cancer in adulthood [Leuk Res 2006; 30(8): 917-22]. http://www.lrjournal.com/.../S0145-2126(05)00466-2/abstract

https://www.ncbi.nlm.nih.gov/m/pubmed/16406019/

MEASLES: Alexander et al found that infection with measles during childhood is significantly protective — it cuts the risk in half — against developing Hodgkin’s disease (OR = 0.53) [Br J Cancer 2000; 82(5): 1117-21].

http://www.nature.com/bjc/journal/v82/n5/full/6691049a.html

https://www.ncbi.nlm.nih.gov/m/pubmed/10737396/

Measles to the Rescue: A Review of Oncolytic Measles Virus. MV Clinical trials are producing encouraging preliminary results in ovarian cancer, myeloma and cutaneous non-Hodgkin lymphoma, and the outcome of currently open trials in glioblastoma multiforme, mesothelioma and squamous cell carcinoma are eagerly anticipated. Aref S, et al. Viruses. 2016.

http://www.mdpi.com/1999-4915/8/10/294

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086626/