All of Cyan's games were in Hypercard up to Myst. (Cosmic Osmo and Spelunx were the other two.)
Myst ran in Hypercard in early Mac releases but switched to a cross-platform runtime Broderbund built to sell Myst on Windows CDs (and consoles and more).
Riven was also majority designed/prototyped in Hypercard as a development platform, but more directly targeted from the beginning that same runtime Broderbund built for running Myst cross-platform.
ScummVM refers to that Broderbund engine as Mohawk [0]. It's interesting all of the other games that used that engine, including several major Carmen Sandiego games. A lot of those Living Books series also felt like Hypercard stacks. I wonder if those Carmen Sandiego editions might also have been at least partially prototyped in Hypercard (though some of them seem to me like they'd be more complex than Hypercard).
Myst ran in Hypercard in early Mac releases but switched to a cross-platform runtime Broderbund built to sell Myst on Windows CDs (and consoles and more).
Riven was also majority designed/prototyped in Hypercard as a development platform, but more directly targeted from the beginning that same runtime Broderbund built for running Myst cross-platform.