Basically, you avoid anything dynamic: model change, tool change, etc it's also important that your system prompt or main prompt doesn't have non-static data like the date/time/place or someone's name (the person you interact with in a chatbot for example). That should be left to tool call or search.
I just put the varying parameters in a trailer prompt and have them change every time. It doesn’t matter because the cache is prefix keyed. You lose caching for the last 20 tokens or so but that’s not a big deal. Moving it to a tool call makes it too slow (needs full roundtrip).
If you’re constructing the prompt you don’t have to jam everything together you can arrange it appropriately.