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by dyauspitr 10 days ago
It’s hard to ignore a link when the n is this large. A 15% greater chance of getting autism is very significant.

A 2024 study of nearly 2.5 million children initially found:

* Autism by age 10: 1.53% with prenatal exposure versus 1.33% without * ADHD: 2.87% versus 2.46%
1 comments
dofm 10 days ago
https://jamanetwork.com/journals/jama/fullarticle/2817406

This is the study you are referring to. I will leave it to others to judge your comment.

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ludwigschubert 10 days ago
> Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analysis. This suggests that associations observed in other models may have been attributable to familial confounding.

To spell it out: the study’s point (sorry, “Conclusions and Relevance”) is to explain away the very data GP cites?

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leereeves 10 days ago
It's a shame this became a high-profile political issue, because there is a real unanswered medical question there, as even that study acknowledges ("associations observed in other models", including that study itself outside of the sibling control analysis).

Also: "However, a 2021 consensus statement by an international group of scientists and clinicians recommended that pregnant individuals “forego [acetaminophen] unless its use is medically indicated,” among other precautionary actions, due to potential risk of developmental disorders such as autism and attention-deficit/hyperactivity disorder (ADHD)."

http://dx.doi.org/10.1038/s41574-021-00553-7

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