[d_silin]

You can absolutely select founding population to be maximally genetically diverse and of large enough number to avoid inbreeding.

Speciation is a likely outcome for interplanetary and interstellar colonies, yes.

[pfdietz]

You can also carry with you frozen gametes or digital genomes. Digital genetic information can be transmitted between systems at trivial cost.

[stasomatic]

Will falling in love be required or will the breeding program be institutionalized?