[khriss]

Recently, even the TDAP (Tetanus) vaccine was correlated with lower incidence of dementia https://news.ycombinator.com/item?id=26919881

I recall seeing a few discussions on HN comments hypothesizing that immune system stimulation via the vaccine might be the root cause. Now that the Amyloid hypothesis is on the wane, hopefully we'll explore other paths.

[zahlman]

> the Amyloid hypothesis is on the wane

Oh? What did I miss?

[Terr_]

I think the short version is that people have developed a lot of things to substantially reduce the levels in human brains, but in practice is doesn't seem to be yielding clearly-good results.

[khriss]

https://news.ycombinator.com/item?id=32183302

TL;DR A lot of evidence supporting the Amyloid hypothesis is suspect.