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Yes I think the drug discovery analogy is apt. I've spent a bunch of time playing with evolutionary algorithms, they're great fun. And when they work they can do surprising things! [edit] I think the drug discovery analogy does have some limits though. Drug discovery isn't a blind search through fitness space, it's informed by physics, chemistry, biology, and medicine. We have many guiding lights to illuminate the space and identify regions (still high-dimensional infinite regions!) that are likely to be productive. There are fewer lights to guide the way on a search for fitness in intelligence. Hell, we don't even know how to write down a decent objective function.

I wouldn't bet on evolving an intelligent, sentient being-in-a-box on a computer any time soon though. I'm of course prepared to be pleasantly surprised.

That said, I think it's pretty clear that LLMs are not going to get us there.