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by cykros 19 days ago
"Most studies have found that dextromethorphan performs the same as a placebo and some suggested it was worse than honey."

Something tells me this is because they're using it at the dosages listed.

Because let me tell you, it certainly does NOT do nothing if you take more...

Part of the issue though is that 1 in 10 people have a CYP2D6 enzyme deficiency and if you take the tablespoon or so that would be more effective (that a pharmacist I used to work with advocated for) you REALLY shouldn't be driving (or going to work for that matter).

Phenylephrine of course is absolute garbage -- they just felt like they had to leave people a placebo for when they took away pseudoephedrine from the shelves to stop people making meth out of it.

Beyond that, I do sort of agree that putting all of these actives into a single product entirely prevents you from working the doses for what actually is effective. If you have a product full of acetaminophen you CAN'T then just take more of it to get the effective dose of dextromethorphan (and I'm not even sure there IS an effective dose of phenylephrine, but if there is it's definitely higher than what's on the label).

Not gonna say "there should be a law!" because I don't think anyone needs men with guns coming for them over this, but I do wonder why anyone buys this crap when the individual active ingredients can all be purchased and used in appropriate amounts.

But I guess most people just take what the label tells them to...