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by myhf 25 days ago
You would get a lot of differences, but the errors would cancel each other out with enough depth of coverage.

This technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.

https://en.wikipedia.org/wiki/Coverage_(genetics)

1 comments

> so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other

This assumes random errors, which IIRC isn't the case for Oxford Nanopore.