[AnodicElegy]

The safety ratios listed in reference [1] are exaggerated, as can be determined by the following qualification: "The majority of published reports of acute lethal toxicity indicate that the decedent used a co-intoxicant (most often alcohol)."

The vast majority of so-called drug overdoses are due to polydrug intoxication. It's much harder to die by consuming a single substance. This is clear from the statistics of the few jurisdictions that report all substances in the blood in coroner's reports. See, for example, the Scottish data from 2020 (https://www.drugsandalcohol.ie/34642/7/ndrdd_report.pdf ): "In 2020, almost all (96%) [drug-related deaths] occurred after the consumption of multiple substances."

[no-name-here]

I imagine painkillers are fairly commonly used for hangover headaches, and it’s surprisingly difficult to get guidance on how long after drinking it’s ok to take painkillers (presumably as it’s complicated) - perhaps instructions should be updated to not just say don’t take with alcohol, but don’t take within a day of alcohol?