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by mikey_p
22 days ago
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I think the thing is that there is no official accepted value of LD50 for THC since there has never been a recorded death from THC: > The median lethal dose (LD50) of THC has been determined in various animal species through oral administration and ranges from 800 to 9000 mg/kg. In humans, there have been no recorded instances of fatal overdoses resulting from acute THC use. However, estimates for a potentially lethal human dose range from 4 to 15 g. https://www.ncbi.nlm.nih.gov/books/NBK563174/ |
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B. Hartung, S. Kauferstein, S. Ritz-Timme, T. Daldrup, Sudden unexpected death under acute influence of cannabis, Forensic Science International (2014), http://dx.doi.org/10.1016/j.forsciint.2014.02.001. Case report of two otherwise-healthy 20-something men who died of cardiac arrhythmia's following large marijuana doses.
https://3402974.fs1.hubspotusercontent-na1.net/hubfs/3402974...
Noble, M. J., Hedberg, K., & Hendrickson, R. G. (2019). Acute cannabis toxicity. Clinical Toxicology, 57(8), 735–742. https://doi.org/10.1080/15563650.2018.1548708. Clinical review of 253 Poison Center cases involving acute cannabis poisoning; 8 patients were admitted to the ICU, 3 were intubated, and 1 died.
https://pubmed.ncbi.nlm.nih.gov/30676820/
There's also a Heyndrickx 1969 paper that everybody cites (including my original reference on hazard ratios), but I can't find an abstract or full text anywhere on the web.
Cases of cannabis poisoning fatalities are extremely rare, but they do exist. Your citation was apparently unaware of (or possibly published before) the other cases.