[CodeWriter23]

Not to chastise you or your wife, there is an actual "Liver Warning" on Tylenol Product labels. They warn against 4000mg/day or with alcohol consumption. It's not an on/off switch, the damage occurs on a ramp that achieves a critical point after so much consumption.

Saying this to encourage label reading and to refute those who might try to characterize your wife's experience as anecdotal. And for those who stop reading a page like this one, after the first paragraph that touts "no evidence": https://www.tylenolprofessional.com/safety-and-efficacy/safe... when at the bottom it reveals the Liver Warning.

[Shortness8]

Alcohol can actually be protective in a paracetamol overdose. Paracetamol itself isn't relatively dangerous, the metabolic product created by the liver is.

Alcohol use acutely reduces the levels of these enzymes which convert paracetamol into it's toxic byproduct as ethanol preferentially binds to the same enzyme for it's own metabolism. Therefore, acute alcohol consumption can reduce the harmful effects of paracetamol.

The reverse is true for overdose in the context of chronic alcohol use, when the liver adapts to long-term alcohol exposure by increasing the levels of enzymes, therefore rapidly metabolising paracetamol into it's toxic byproduct and worsening harm.

Source: doctor

As a side comment, the lack of medical knowledge displayed in HN threads paired with the absolute confidence some verdicts are delivered with is worrying, and something I thought this forum would be better at than other sites (looking at you, reddit). Paracetamol and NSAIDs (including ibuprofens) are safe drugs if taken to the package directions. Some of the ideas shared in this thread about taking one over the other, or not taking one ever etc, are not rational. Please consult your doctor if you are worried about your particular situation, but generally OTC medicines are not dangerous if taken to the package instructions.

Accidental overdoses of paracetamol are exceeding rare, but intentional ones are common.

[AngryData]

Its obviosly more dangerous with medicine but I see the same thing with other non-tech topics here like agriculture and construction trades so I always take non-tech topic comments with a grain of salt on here. There is a good diversity of experts on here but of course they can't be expected to correct everybody all the time.

[IAmBroom]

Expert fallacy: I know a lot about X, so I'm also an expert on adjoining topics V, W, Y, and Z. Also on topic "ecks". And "x-rays". And "excerpts" and "excommunication". Ah, hell: I'm smarter than most, so I'm usually right. Especially about things I'm sure I right about.

[jambalaya8]

It appears his wife took under that threshold and only for a few days. 4000mg is roughly 8-10 otc painkillers in a day (depending on the brand).

That said, everyone's physical ability to metabolise drugs is different. I might worry something else was wrong, or at least get a followup test done later, if her liver tox screen showed that, just to rule out another cause.

[cykros]

Everyone's ability to metabolize drugs being different has a lot to do with why the labels end up advising less than is effective for many people. Dextromethorphan surely is NOT ineffective, but at 2 tsp, yea, it aint gonna do much of anything (unless you're CYP2D6 deficient -- then, it may still do a LOT depending on how deficient).

[looptylou]

You're right: metabolisms vary. This is why I don't dance with the 4 gram limit, even though (insanely) post-op instructions regularly advise you to.

[inigyou]

Out of context on the /comments page, one might think you are talking about completely different substances, heh.

[Forgeties79]

>or with alcohol consumption

This part is what a lot of people miss IME