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by nostrademons 25 days ago
Yes. 4g is generally considered perfectly safe and is fairly commonplace dosing. 7g can kill you. Hence a therapeutic index of < 2.

This is why you have to be very, very careful. If you're doing 8 500mg Tylenol pills and then you also do 6 doses of DayQuil or Mucinex without realizing it's also acetaminophen, you can end up needing a liver transplant.
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Scroll_Swe 25 days ago
I wonder why it is not a more commonplace useage for suicides. Females seem to enjoy overdoes more, and men seem to enjoy violent ways. But female sucicides often "fails", seems like eating a box of Tylenols (here they come in 20 packs) would solve the "being alive" issue quite quick, no? Better not tip people off... :)

>end up needing a liver transplant

You won't get one nor should you get one if the reason is this.

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annzabelle 25 days ago
Calling women females and men men in the same sentence is really something. Same with the smiley face in a comment about suicide.

Intentionally overdosing on Tylenol gives you a day or so afterwards to panic and seek medical attention and probably live instead of dying a horrible death. More violent means do not give you any time to retroactively back out of it.

And, yes, in America at least, some lucky people do get liver transplants after acetaminophen overdoses, occasionally even intentional ones.

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nostrademons 25 days ago
It's a pretty terrible way to go. Death doesn't come immediately; you seem fine at first, and then about 3 days later you suffer intense abdominal pain and vomiting. At about 4 days you realize your liver is irreversibly shot and you're a dead man walking unless you can get a liver transplant. Then you enter multi-organ failure as your body and brain shuts down.

Acetaminophen poisoning actually featured on two episodes of House, and one of them had the suicide plotline. In S05E11, "Joy to the World" they suspected an overweight teen OD'd on acetaminophen trying to kill herself, but the actual diagnosis was eclampsia from an undisclosed pregnancy. In S06E10, "Wilson", a friend of Wilson's suffers acetaminophen poisoning while trying to manage his back pain.

https://house.fandom.com/wiki/Joy_to_the_World

https://house.fandom.com/wiki/Wilson_(episode)

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Scroll_Swe 25 days ago
I did marathon house for a bit, love it! Thank you!
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cykros 23 days ago
Most intentional overdose suicides are hoping to drift off to sleep and not wake up. That is NOT what happens with an acetaminophen overdose.

It'd be like intentionally eating death cap mushrooms.

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SubmarineClub 25 days ago
Probably because most people realize that it’s a horribly unpleasant way to go about it?
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