[declan_roberts]

Some downsides:

1. They make you stop eating, which for most of human history kills you.

2. They are a life-long treatment and kind of expensive unless you go gray market.

3. Gastrointestinal issues especially when titrating up.

[chrisco255]

1. They don't make you stop altogether, they just make you feel full on less calories, which is good when you are in a calorie dense environment like modern society.

2. Not necessary here either if dietary habits are permanently altered, which can happen more easily after several months on GLPs.

3. Perhaps!