[SubiculumCode]

And this morning, I cut another hole in my belt. Turns out, losing weight and being thin was never about willpower or laziness in the face of absolute food abundance. It was mostly about whether a person was born lucky enough to have a moderate appetite, or was born burdened by exaggerated appetite.

The underlying issue is physiological food cravings, not some personal failing or lack of willpower, and GLP-1 absolutely addresses those "underlying issues". That it isn't some one and done pill is hardly a realistic expectation as that would require probably genetic and epigenetic reprogramming.

[nihonde]

The idea that appetites are assigned at birth is a bold claim. Is there evidence to support it?

[9x39]

Well, not assigned by the hospital or your parents, but being a DNA-based lifeform a genetic baseline is a safe assumption. Experiences vary after that:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3052625/

[s1artibartfast]

I think there is much stronger evidence that it is metabolic damage from overconsumption in an earlier stage in life.

Not unlike if you shatter your legs, your recovery may be long and incomplete.

[SubiculumCode]

Genetics and epigenetic factors.