[trevithick]

The article doesn't address treatment efficacy in humans. How is it treated? How effective is the treatment? Can this develop resistance to the treatment? The spread mechanisms and persistence are concerning, but without info on treatment I'm not sure how much I should freak out about this.

[zelse]

We have very few effective antifungals, and discovering new ones is an order of magnitude harder than discovering new antibiotics due to fungi being more closely related to animals (what's toxic to them is often toxic to us). Resistance is an ongoing problem and will worsen in time; Sporothrix already has strains that are resistant to mainline treatment. I recall reading that at least one developing fungal pathogen of concern is in practice impossible to clear from the body fully once established with existing antifungals.

A further issue still is that some fungi exhibit extreme resistance to sterilization; one of the nosocomial emerging fungal pathogens of concern, for example, can easily survive the peroxide fogging technique often used to clean high-risk hospital rooms even at several times the standard exposure duration and concentrations.

Additional issues include treatment compliance - clearing fungal infections can require taking the drug for months without missing a dose.

We should be very concerned about emerging pathogens in light of anthropogenic climate change, but with proper funding and attention this is not necessarily apocalyptic.

[NoMoreNicksLeft]

Candida is already antifungal resistant in many cases, or so I remember reading.