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by amanaplanacanal 3 hours ago
I suspect that blood vitamin D is mainly a marker for how much outdoor exercise people are getting, and that it is the exercise rather than the D which is causal.
7 comments

My life changed after I got tested for vit D and started talking supplements. I was severely deficient. I am now sufficient and everything changed for me.
In December by chance I put a pack of Vitamin D into my shopping basket. I did not think much, thought to take 1000IE but then decided that for the first week I take 3000 to catch up. Muscle pain went and control over eating improved. I did not expect any changes based on past experience with 1000 but this time I could not ignore it (age can play a role) and I stayed on 3000. Tests a month later showed I was just not deficient any-more. I continued on the regime and started having improvements in long running skin issues to the extent my dentist noticed. It may not be a miracle drug but one should not underestimate cumulative impact individual factors, age and lifestyle changes (less sun) that may change levels and demand.
I used to take 4k IU + K² and think that I'm covered, since 4K units was a lot.

I landed on just above deficient when tested.

My wife was on kind of same regime, but didn't follow it very strictly. She was deficient, but not extremely.

It was quite surprising, because I got warned when buying 4k unit tabs that they were quite strong and pharmacy clerk suggested taking less.

I am deficient, too, and take supplements (rare liver disease).

I wonder if taking mushrooms soaked in the sun improves absorption compared to supplements?

That doesn't undermine OP's point. Being deficient is unhealthy. But that doesn't mean an overabundance makes you healthier.
What exactly changed?
How do you know the changes aren’t placebo?
Keep in mind vitamin D is really, among other things, an immune signaling molecule.

So, we know the mechanism, and it's quite plausible that supplementation works.

In other words, as an skeptic, I don't think it's just an epidemiological correlation.

I also suspect that the frequency of outdoor exercise matters even if the total duration of outdoor exercise remains the same. Subjectively, I feel much healthier when doing thirty minutes of outdoor exercise six times a week, than when doing one hour of outdoor exercise three times a week. But then of course, all the causal effects could have been caused by a different factor (say dopamine release) than vitamin D.
Ding ding ding.

People who are drawing blood and trying to find some correlation between vitamin presence and health at this point are just practicing divination. The fact that it can be published in a scientific journal without any sort of RCT to back it up is palpably unscientific.

The customers of these studies are the supplement companies looking for another product to sell.

But then why do we see improvements in people that get vitamin D + K2 supplements and not exercise?
As the article mentions, we pretty much don't see improvements with supplementation.
I don’t think there’s anything definitive. 400IU/day from one study is nothing if you’re deficient. 2000IU from another study is better, but even then we don’t seem to know much about absorption from these studies. For example, did it actually raise serum levels by 10ng/ml after a year, and how did THAT correlate to positive or negative health outcomes? K2 also seems to play an important symbiotic relationship with D, and seems notably absent from these studies.
From the article:

> the balance of evidence tips pretty clearly in the direction that people with low-ish levels would be wise to supplement

Yeah, I wish the article had brought Vitamin K2 into the mix since that seems trendy to pair with your D3 these days.
Maybe this is true if you’re only considering white people. Brown people can spend a lot of time outdoors and still be deficient, especially if their ancestry is from much a much sunnier region or lifestyle than the one they’re currently living in.
Indeed: “Vitamin D deficiency in western dwelling South Asian populations: an unrecognised epidemic” … “27–60% of individuals, depending on season”

https://pmc.ncbi.nlm.nih.gov/articles/PMC7663314/?utm_source...

It has never been established that darker people require the same amount of D as lighter. The supplement industry plays on these fearmongering to boost sales.
It depends on one’s whereabouts and kind of exercise. Exercising in a gym or outside with all your skin covered won’t make much vitamin D.