This Q5_K_M quant should be near lossless and fit with full 256K context in about 100GB of RAM: https://huggingface.co/AesSedai/Qwen3.5-122B-A10B-GGUF
Edit: specifically Qwen 3.6 27B beats that on coding and agentic workflows.
Edit: specifically Qwen 3.6 27B beats that on coding and agentic workflows.