Noise cancellation headphones that will block out loud things or ambulances approaching you, sitting exposed on a motor strapped to two wheels at a high speed? Yes. That is different from driving in a Lexus.
They don't block out loud things or ambulances approaching you. They block out constant loud background noise. This is why they're good for airplanes, lawn mowers, motorcycles and being out in public, and not good for shooting or as industrial hearing protection.
As I mentioned in another comment, on an airplane, my airpods in ANC mode make it easier for me to hear announcements.
I drive a car and ride a bicycle and an e-bike in Miami. The ANC isn’t that magical, I hear plenty of out of the algorithm noises (ambulances, etc). Head on a swivel and look straight.
+1, but add a motorcycle to that list too. Not Miami, but a large city, and now a smaller city.
All the assertions I'm seeing in this thread are bizarre to me. One can easily hear a siren over noise cancellation and over wind noise, and it's even easier to hear if you have noise cancellation for that wind noise.
As a related example, when I'm on an airplane and I have noise-cancelling headphones on, the pilot announcements are easier to hear than without them.
As I mentioned in another comment, on an airplane, my airpods in ANC mode make it easier for me to hear announcements.