[A_D_E_P_T]

Heavy life challenge: Biology usually discriminates against heavy isotopes. Can we reverse, redirect, or exploit that tendency? Find a way to get plants and bacteria to preferentially incorporate heavy atomic isotopes.

Use microbes, algae, duckweed, or plant-cell cultures to produce deuterated and 13C/15N-labeled complex biomolecules that are expensive or impractical to synthesize chemically.

Could be fun, honestly.

[azalemeth]

I know you're joking, but changes in isotopes mildly affect reduced mass and hence enzyme kinetics. Maize and other C4 plants already preferentially enrich themselves with 13C [0-3] which occasionally buggers up metabolomic experiments. Famously, a few drugs use 2H rather than natural abundance H typically in order to exploit a kinetic isotopic effect and get a better Km in their binding pocket [4].

[0] https://en.wikipedia.org/wiki/Fractionation_of_carbon_isotop... [1] https://pubmed.ncbi.nlm.nih.gov/7577891/ [2] https://pubmed.ncbi.nlm.nih.gov/1734681/ [3] https://en.wikipedia.org/wiki/List_of_C4_plants [4] https://en.wikipedia.org/wiki/Deuterated_drug#Examples

[TeMPOraL]

Personally I don't see this as joking, I think this whole space is severely underfunded and could use some publicity and moonshot contests. I mean, think of it, the planet Earth is full of beautiful and diverse nanotechnology that can literally map-reduce complex behavior over individual molecules, and we do so little to use it for practical purposes. Even most advanced manufacturing methods we use are still simple things applied in bulk, counting matter by volume instead of as objects. There's lots of unexplored potential within reach, and here we actually know it can pan out, because we see these processes happening everywhere, all the time, all at once, all around us.