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A lot of people here in the comments saying 'this can't work because amyloid beta hypothesis was wrong' seem to be missing that this treatment is aimed at some of the primary mediators of general brain health (function of natural BBB/vascular waste clearance mechanisms, which seem to degenerate over time, and modulation of neuroinflammation), not just clearing AB proteins pharmacologically. This jibes well with the stated improvements in Parkinsons and ALS. I doubt there is one root cause of Alzheimers (except maybe in some genetic cases), and this is likely not a panacea, but sounds like it may assist some of the key processes involved in breakdown. Root behaviors related to sleep quality and quantity, diet, exercise, infection, environmental exposure and stress, as well as genetics, likely all contribute. But, waste clearing and neuro-inflammation seem to be core processes involved in the progression of the pathology, and improving natural vascular waste clearance seems like a logical place to find at least a small improvement in progression and symptoms... Analogy: if someone puts metal shavings in an engine, having a better oil filter won't prevent all damage caused by the person putting the metal shavings there (nor will it halt the process), but it will reduce the damage by getting those shavings out of circulation before they have a chance to make even more repeated passes through the engine and do even more more damage. Improved vascular waste clearance is likely only a small piece of the puzzle, like having good oil pressure and filtration, but that doesn't mean it's irrelevant just because it doesn't prevent the other upstream root causes! |