[estearum]

My implication is that there are indeed large scale changes that are totally concordant with large scale endocrine disruption.

Desire to mate, sperm count and quality, rising obesity, falling testosterone, increases in testicular, prostate, and breast cancer, increases in autism and attention disorders, etc. etc.

It's ridiculous to say that we know these aren't causing problems because "we haven't seen problems." We do indeed see very, very big problems population-wide that are similar to what we see in the lab when poisoning mammals with these chemicals.

Presumably none of these problems is caused exclusively by EDCs, and potentially none of them are caused by EDCs at all. But there are plenty of changes worth investigating.