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by code_biologist 7 hours ago
I've seen exactly this behavior on claude.com with no system prompt with Opus 4.8 specifically, especially around chronic illness stuff where there's established mainstream medicine dogma and reddit / internet communities with alternate causality theories and treatment approaches (PMDD and MCAS-adjacent illness). 4.6 is happy to analyze and consider them, 4.8 really doesn't like the alternate theories and treatments.