| I'm no expert, but p53 is known as "the guardian of the genome." If p53 is reactivated, the cancer cell dies. https://en.wikipedia.org/wiki/P53 Perhaps a different mutation that disables p53 could evade the pattern match. This article is all about p53. Edit: This section of the wiki best explains this critical cellular component... p53 regulates cell cycle progression, apoptosis, and genomic stability through multiple mechanisms: -Activates DNA repair proteins in response to DNA damage, suggesting a potential role in aging. -Arrests the cell cycle at the G1/S checkpoint upon DNA damage, allowing time for repair before progression. -Initiates apoptosis if the damage is beyond repair. -Essential for the senescence response triggered by short telomeres. |