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by MontyCarloHall
12 days ago
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Even with 100% delivery efficacy, editing efficacy is nowhere near 100%. CRISPR/Cas editors will reliably detect the target sequence but will not reliably edit it in order to repair the mutant allele, whereas CRISPR/Cas12a2 will activate and destroy chromatin ~100% of the time when it detects the target. As is often the case, it's a lot easier to indiscriminately destroy than precisely (re)build. |
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