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by shevy-java 6 days ago
Why does it take 20 years? Except, of course, that it does not work nowhere near as well as it is being promoted - aka hyped.

mRNA vaccines are also quite different. Do they modify the DNA? Of course not. So that's already very different.
2 comments
ufmace 6 days ago
One of the reasons is, you don't get really good data on how something works until you start running clinical trials for it. It's all very time-consuming - having to plan how the trial is going to work, getting approval for it, finding subjects who meet the criteria (here, a specific type of cancer at a specific stage probably) and sites near them willing to work with you, manufacturing and shipping the treatments, and only then can you start gathering data. If it didn't work, you gotta start over, And it all costs a boatload of money too.
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perlgeek 6 days ago
Let's see... first of all, 14 years ago was the discovery of the base mechanism, not of specific treatments. So specific treatments need to be developed, delivery systems need to be developed, side effects reduced. Then you need safety tests and efficacy tests.

> mRNA vaccines are also quite different. Do they modify the DNA? Of course not. So that's already very different.

And yet it took more than 30 years after the first mRNA experiments to develop a successful vaccine. Why it should be so much faster for CRISPR & Co?

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