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Tangent to this topic, if you are deficient or sensitive to B vitamin supplementation, it may be worthwhile to get tested for MTHFR/COMT genetic variants.

https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_redu... https://en.wikipedia.org/wiki/Catechol-O-methyltransferase

If you've done 23andme, ancestryDNA, etc, you can likely just use your raw data to get this information.