[Aboutplants]

First of all 5mg is a standard medical dosage for this medicine and isn’t likely to produce horrible experiences that you would get with much larger doses.

Second, you think it’s more ethical to let a patient suffer? Are you against emergency surgeries where a patient is unconscious after a car accident?

[dwroberts]

The dose in the paper is 5 grams, not mg

> Second, you think it’s more ethical to let a patient suffer? Are you against emergency surgeries where a patient is unconscious after a car accident?

My concern is that this induces more suffering. They are going to gain lucidity and then lose it again. That must be deeply distressing (for the family/relatives too). Can’t imagine that psychedelics help with the state of psychosis/hallucinations that advanced Alzheimer’s patients already experience too

[sendmarsh]

From the Frontiers paper: "The patient received 5 g of orally administered psilocybin-containing mushrooms (Enigma strain". i.e., a standard dose of 5g of mushroom.

[dwroberts]

I’m assuming you’ve never taken mushrooms before (on average there is probably ~10mg psilocybin per dried gram, so 5g is 50mg which is on the high end of dosing, definitely not ‘standard’)

[jfyi]

We don't know they were dried. We do know the strain is a particularly potent one that grows in a fashion that might not lend itself to normal water concentrations.

Really though, weren't you the one conflating mushroom dosages with those of pure psylocibin a moment ago? I find it difficult to believe someone with more than incidental experience would make that mistake.

[dwroberts]

> Really though, weren't you the one conflating mushroom dosages with those of pure psylocibin a moment ago?

I think you’ve misunderstood. I was quoting the paper, which states 5 grams. 5 grams is a lot of mushrooms, especially for someone who is not compos mentis. 5g implies probably ~50mg of psilocybin, I haven’t been conflating them at all (you measure the amount of mushrooms because obviously you can’t see how much psilocybin is in each one).

If the paper stated an exact dose of psilocybin this would be a totally different discussion

Edit: I just realised the quote in my first comment incorrectly states 5g psilocybin- I didn’t ever understand the paper as meaning that, I just wrote that incorrectly. All of my subsequent comments were talking about this as 5g mushrooms - which is still a heavy dose!

[jfyi]

No worry, cool. Easy to do, sorry to press. It just seemed weirdly aggressive calling the other guy out after that and I felt the need to address it.

[sendmarsh]

Let me clarify. A "medically" standard dose. My personal preference would be 1-3g.

[porksoda]

I just got to the bottom of your argumentative thread and I just got to say: "says you".