[kranke155]

I’m not even sure you understand how evidence based medicine works.

Afaik evidence based medicine ranks mechanistic analysis near the bottom of the hierarchy — below controlled trials and systematic observation. I believe that ordering was a deliberate choice.

You seem obsessed with something that modern medical research often doesn’t focus on - by design. We still don’t know how lithium works 50 years past its introduction. We don’t know how the conditions that it treats - psychosis or bipolar - work either. Yet lithium is used all over the world- because the effects data and reports show that it works. Your mechanistic obsession isn’t just wrong - it’s directionally incorrect as far as a lot of medical research goes.