[danilocesar]

Installing plain fedora in an external nvme drive and boot from there works pretty nicely.

Luks, uefi, fstrim, everything works fine. I boot it from my desktop, laptops or from virt-manager when I need a quick change.

The only thing I couldn't make it work was the proprietary nvidia drivers.

[pjmlp]

I once killed the installation of a work laptop, with such an approach.

I used an external SSD disk to run Linux from it, and one day whatever happened while shutting down the OS, killed the partition on the internal drive.

Thus making me having to request a fresh installation of everything, and losing some stuff in the process, as that killed the cryptographic key for the disk as well.

Never again, lesson learned.

[danilocesar]

Can you talk more about it? So an issue during shutdown running from the external drive destroyed a partition of a internal drive?

I can see power issues corrupting the external drive (and I can live with that), but I'm wondering what went wrong in your case.

I'm not sure running the whole thing from a live-boot (which is kind of the point of the topic, different from a external installation which is what I use) would have prevented anything.