No. The multiplexers are all turned off, and I have devd/udev rules that spawn my own userspace driver processes (as services, via service management) to attach to the individual USB devices. The driver services in turn use an autoconfiguration system to determine whether they should actually attach to the device whose name they are passed, and where they should pass input onwards to.
This is for a virtual terminal system. For X11 or Wayland, one would have to replicate the same idea in an appropriate form, and stop using the multiplexed devices.
* https://jdebp.uk/Softwares/nosh/guide/user-virtual-terminal-...
* https://jdebp.uk/Softwares/nosh/guide/commands/user-vt-reali...
This is for a virtual terminal system. For X11 or Wayland, one would have to replicate the same idea in an appropriate form, and stop using the multiplexed devices.