I routinely use it over a 5G mobile connection, often while moving, far from any datacenter, and it's usually fine as long as my signal is good. They do a fantastic job out of squeezing what they can from your connection.
I'm actually some 200 miles from the data center, but Nvidia has been doing a stellar job in connecting to the backbones of all the major ISPs around. If I actually lived down the road from them, it would be as low as 1 to 2ms, as reported by plenty of users. This isn't uncommon, especially in the EU.