It seems to have originated with Eugene Wigner's 1960 "The Unreasonable Effectiveness of Mathematics in the Natural Sciences".
Now it's the Unreasonable Effectiveness of "The Unreasonable Effectiveness of X".
It seems like "X is All You Need" is All You Need.
[1]: https://web.archive.org/web/20090320002214/http://www.ecn.pu...
But then, this thead is all about proteins incorporating structural cliches, isn't it?
It seems to have originated with Eugene Wigner's 1960 "The Unreasonable Effectiveness of Mathematics in the Natural Sciences".