[siva7]

> More than 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene.

So pancreatic cancer is basically a genetic disease for most patients instead of environmental?

[roadnottaken]

No, the KRAS mutations are somatic (spontaneous), not inherited

[AustinDev]

So presumably something causes the spontaneous mutations?

[M95D]

Nature.

DNA is unstable. Lots of stuff cause mutations: background radiation, chemicals, viruses, even our own normal metabolism [1].

[1] https://en.wikipedia.org/wiki/Reactive_oxygen_species#Oxidat...