[chopete3]

Most of the human moods, energy levels, immunity, recovery, consciousness can be controlled by chemicals. It is no surprise that continuous use of a chemical will have impact.

The worry always is what does that extra chemical destroy as the body doesn't produce it naturally.

[citadel_melon]

Creatine has been tested over long time spans already so this comment is not applicable here.

The better rebuttal is that the paper didn’t follow RCT protocols.

[diego_sandoval]

Creatine is one of the most studied substances that humans consume.