[the_sleaze_]

A good question, but we don't know what anti-depressants do or how they do it, same with anti-psychotics, mood stabilizers, psychedelics, etc. I think we can say we have good theories for creatine.

We do know that it does do something at certain doses.

[j45]

There are lots of studies. It's possible to find satisfactory information. Creatine has been studied for a very long time.

First hand experience for many is a noticeable improvement, especially during busy/sleep minimizing times, to the point where it can sometimes be a substitute for caffiene without the crash.