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by throwmeowaway 16 days ago
I also have MTHFR gene mutations and sleep issues.

What exactly helped you?

1 comments

As a vegan you dont get any creatine since you're not eating meat, so your body has to make it itself, which requires a ton of methylation and if you're like me and have bad genes for methylation your body had a hard time with it as it is. So by supplmenting creatine you're reducing some of that burden.

As far as sleep goes, high dose creatine has been studied to have an extermely positive effect on brain function during sleep deprevation, better than stimulants/caffine

I think the prescribed dosing for creatine and sleep deprevation is 0.35g per KG, much higher than the typically recommended dose of 5gs a day for muscle. The positive effects on the brain come at much higher doses. Which is perfectly safe for your kidneys, this is a myth (as long as you dont already have poor kidney function).

https://www.nature.com/articles/s41598-024-54249-9

https://pubmed.ncbi.nlm.nih.gov/16416332/

Also note, that if someone is going to start taking creatine they need to up their hydration - likely a lot.