[TiredOfLife]

Following that guide for first reading is probably the biggest mistake I have made in my 42 years of being alive.

First time you read it should be in publishing order.

[simonw]

I think it's OK to skip the first two.

Those two Rincewind novels were when the Discworld books were parodies of the fantasy genre curca ~1980. If you aren't aware of the tropes of that genre the jokes don't hit as well.

From Equal Rites onwards Terry realized that the Discworld was much more interesting as a lens to reflect on human society. That idea kept him going for the rest of the series.