Live dissection and experimentation on “alive but drugged” human brains is mental. How do you ensure that you aren’t torturing a brain that can’t see, hear or scream? How are you held accountable?
When I had my ear surgery about 20 years ago, the doctor explained to me that I would be awake for part of the procedure, but the anesthesia meant that I would have no memory of it.¹ It’s a weird thing to think about whether that lack of memory would obviate the pain or discomfort of the moment.
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1. As it turned out, I was so frightened in the lead-up to the surgery that they had to do general anesthesia on me because I was shaking too much for them to operate so I was unconscious for the whole thing.
Purely anecdotal, but I had surgery a few years ago (relatively minor). But I could feel for months after a sort of 'unconscious PSTD' I don't know how else to describe it. Even after it was healed and the pain was gone, there was just a deep sense of 'something bad happened in there' feeling. I'd have dreams of someone digging around in my body. Anyway, it's all gone now, but a weird experience for sure.
I have vivid dreams and smells from a surgery where the visions and feeling of them poking me are incredibly intense. The question is whether it’s a memory or a manifestation of fear. I rarely dream (every few years), but this vivid dream comes through on occasion.
I had the same thoughts "but won't i feel it THEN?" when I was getting an upper endoscopy. The anesthesiologist said you're in such a trance, dreamlike state plus with the inability to form memories its like you're not your real "consciousness" but something different. Sort of like your brain is in "limp mode" and its not really _you._ This was both comforting and slightly terrifying in a different way.
I've had an upper endoscopy and a colonoscopy, both the same day, and both without anesthesia. If they didn't take a biopsy, it likely shouldn't have been too traumatic, consciously or subconsciously - maybe that's a bit comforting to know.
I do remember my lung biopsy where they went in down my neck. Maybe they give less drugs for that than for your upper endoscopy. My memories have a slightly horror movie vibe but I would not be put off having the procedure again.
You might have been dreaming. I had a memory of the doctor saying "clamp down" and I bit down on the endoscope and he said "not you." I asked him if that happened and he said nothing like that happened at all and it was just a false memory/pseudo dream. Or he was lying to me.
I remember there was a lawsuit when a guy left his phone recording when they wheeled him in for a conscious sedation procedure and the doctors and nurses were making fun of him audibly how fat he was. Seems like they're confident enough in people not remembering for them to do that - or being able to dismiss it.
I had a dentist explain to me the same for getting my wisdom teeth out, as if it was a selling feature. At least for me, having my memory wiped is far more scary than just being put unconscious (or having some pain and a local anaesthetic).
I was one of the last if not the last patient the dentist who took out my wisdom teeth gave general anesthesia to (at my request, he was normally only doing local). Afterwards, the whole dental office staff (and my mother!) entertained themselves with having conversations with my incoherent self as I came out of the anesthesia. Apparently, I declared that I was ruined and would never be able to sing opera again (point in fact, I had never sang opera before).
A colleague warned me of the same when I was having my wisdom teeth removed. As a result, while I was being put under, I was very focused on the effects of the anaesthetic. I feel about as confident as one can be that I was completely unconscious during the entire operation. I remember the surgeon asking me to count to ten, and the specific feeling of my vision melting and swirling around, before suddenly waking up with the surgery over.
When I wake up from dreams, even with no memory of them, I sometimes have "a memory of a memory"; the tip-of-tge-tongue feeling that there's something interesting I'd experienced, but which I now can't remember what it was. But with the anaesthetic, there wasn't anything like that at all.
Similar for me, although I did not realise I had gone under. I counted to ten, and when I reached ten I opened my eyes and was in a different room and the surgery was over. Very weird!
Had a few eye surgeries (vitrectomies) under sedation, no pain but lots of flashing lights and lots of kaleidoscope patterns. It was pretty wild.
I was lucky that coming out of sedation was actually fantastic, like the only time I can remember feeling that blissfully relaxed was in maybe a few beach holidays I went on as a kid.
The doctor who did the surgery was arguably the best doctor I’ve ever interacted with in my 57 years of life. He was horrible at starting appointments on time (much to the frustration of his staff) because he would spend as long as he felt necessary with each patient, regardless of what the scheduled appointment length was. He was essentially at war with insurance companies about coverage limitations (for the procedure, a stapedectomy, insurance companies wanted to have this be an outpatient procedure but he felt it was better for patients not to have to be in a car immediately after surgery so he informed patients beforehand that they would be checking in as an outpatient and he would declare complications after surgery that required an overnight hospital stay. Similarly, the antibiotic that the insurance companies had as their preferred formulary had a tendency to kill hair cells which made it a bad choice for in-ear application. All of his patients were advised that they had an allergy to this antibiotic and thus would have to be prescribed his preferred antibiotic). So, with this doctor, if he told me that the moon was made of green cheese, I would believe him without reservation.
I've thought a lot about this. If you experience immense pain for half a second, then immediately forget, it doesn't seem so bad. And anything bad that has happened to you that you completely forgot doesn't really affect you. Sometimes when I'm feeling ill, I'll think to myself, "If I remember having this thought, then this sickness is terrible, but if I forget the whole experience, it isn't. If I eventually forget this happened, then this current pain is not real." Then when I remember that, I know that moment in time contributed to my total self. But surely I have also thought this without remembering it.
Does a full day of torture, completely forgotten, really matter? How long before it does matter? We forget vast amounts of our lives constantly. And after death, forgetting everything, how much mattered then? It's a mindfuck.
It wouldn't matter even if you remembered it, if it wasn't for PTSD. That and the waste of a day.
The last question is strange, it implies that the goal of life is to fill up a trophy cabinet with golden memories and then, I guess, relish them for eternity, rather than to do things.
A life where I remember good memories is worth a lot more to me than a life where I do great deeds while sleepwalking and have no memory of it. What's the point of doing something if you don't even know you did it?
Oh yeah, I've had two cath lab visits. In both of them, I woke up in the middle of the process, conscious enough to recognize that the black-and-white image on the screen was me with a wire in my heart and little puffs of dye.
The first time it happened, I was fascinated watching the process. I thought I asked them a question about what I was seeing. I probably was just mumbling. The second time, I had a bright white ball of nuclear fire in my chest, and in my mind's eye, my ribs were slumping under the heat. I tried to tell them about the burning sensation, and I apologized for complaining (one should always be polite to the doctor running a wire through one's arteries and into one's heart).
In both cases, after I tried to speak, the room went black again.
As I relate the story, I can see how, for some people, it would be nightmare fuel. But for me it was this abstract "hey, that's cool."
I'm in the UK and was intentionally kept conscious during angioplasty and stent placement. Mind you, it was an emergency heart-attack kind of appointment! The experience was very cool and I recall that the wire-wriggling cardiologist wore a sectional lead suit (rapidly firing X-ray machine) and to my drug-addled brain, reminded me of the armored gorillas in the Planet of the Apes movies.
Colonoscopies used to be like this in the US more often (“you’ll be awake but won’t remember it”). I feel bad for the me that existed in that time window of discomfort. 20 years later they did general anesthesia (family history of colon cancer).
I had a low stakes cyst removal from my butt crack once. Sparing the other details, the anesthesiologist explained the different drugs, one to numb, one to prevent my memory from forming. I asked if they could leave out the memory drug and I could remain cognizant. She didn't mind and I had a nice chat with her about anesthetics while on my stomach having doctors cut out part of my butt.
> The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures.
I recognized that anesthetic from its famous irresponsible use-
"Attention to the risks of off-label use of propofol increased in August 2009, after the release of the Los Angeles County coroner's report that musician Michael Jackson was killed by a mixture of propofol and the benzodiazepine drugs lorazepam, midazolam, and diazepam on 25 June 2009." https://en.wikipedia.org/wiki/Propofol
Used properly, however:
"To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental."
The media and the people who bought into their shameless attention-grabbing lies are the reason he had sleep problems. He was unanimously acquitted of all counts, but the media made his life into a living hell by consistently portraying him as a pedophile because it drove incredible engagement numbers. A justice system should be "innocent until proven guilty", and yet MJ was deemed guilty even after proven innocent. Longform read from an actually good journalist, if you care to learn for yourself: https://www.huffpost.com/entry/one-of-the-most-shameful_b_61...
That article was written 16 years ago and misses a lot as a result. it doesn’t mention the new allegations, including those documented in Leaving Neverland. It also glosses over the accusations in the 1990s. It’s papered over that those allegations were lies, but he settled the lawsuit with them for over $23M.
I mean, he may have never done a sexual thing but his pedophilia was quite obvious and the degeneracy of parents to allow their children to spend the night in the bed of a grown man is not really good for society.
It's not only not been proven, but the island man stuff and testimony of people like Culkin suggest he actually did the opposite of doing bad things to children and was most likely a scapegoat for the "elites" of Hollywood because of his race.
At the very least drop an "allegedly" or something to make it sound a little tasteful.
I think there is worlds between definitely defining what consciousness is, and what are some of the scenarios and conditions under which consciousness cannot ever happen.
And on top of that, they put a sedative, just in case.
It's not a great article, and it glosses over the reality that if you hooked this brain up to an EEG it would show unequivocal brain death. CELLS of the brain are alive, but in terms of being able to function in any sort of coordinated way there that ship sailed minutes after the person who donated their organs died. The wave of depolarization that marks brain death isn't something we can reverse, and what's being done here is all about metabolism and structure rather than those much more subtle functions.
IMO the more questionable aspect of this entire operation is the use of "AI" to reach conclusions about how the test molecules are being metabolized, but that's a lot less compelling than implying that some company is somehow preserving life in a disembodied brain.
The word "alive" is doing a lot of work here. A brain is pretty much permanently fried after five to fifteen minutes without oxygen, and these are donor brains, not some emergency brain extraction team, so the timeframe will be much longer than that. There might be 'life' left in there in the technical sense, but there's no 'person' left.
Well, we know how to make living brains insensate - that's who we all make it through surgery.
Presumably they're doing something similar - or using some other well-understood mechanism - to ensure that's not the case.
> The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures. Bexorg obtains brains in partnership with organizations that procure donated organs for transplantation, and Vrselja says once families understand the company’s process and goals, their response is overwhelmingly positive.
We know anesthesia "works," and we know some of its molecular targets, but we do not fully know the mechanism by which it produces unconsciousness, ie whether anesthesia eliminates experience, or mainly blocks memory, report, and integrated neural processing.
The most important thing to know about anesthesia in the context of OP is that it often doesn't work. 'Anesthesia awareness' is real and probably more common than we think because anesthesia can easily produce awareness but block memory formation.
"What did the doctor say? He told me that they couldn’t up the anesthetic because an overdose could cause respiratory arrest, and that it wouldn’t matter because the
anaesthetic on any dose caused severe short term memory loss and whatever happened the patient would forget all about it.
The second point, at least, was right on. One patient spent the entire procedure writhing in agony and screaming something incoherent to God. The doctor finished the procedure, took out the endoscope, and cut off the anesthetic, and the patient turned his head, looked the doctor right in the eye, smiled, and said, laughing “Wow, that wasn’t bad at all!
Guess I slept right through it!”"
Anesthesia appears to be a fairly broad effect - anaesthetics work on plants, for example [1], even though they lack any neural tissue whatsoever. It would be extremely surprising if those effects were also targeted enough to halt only some types of brain activity.
My understanding was that we now believe that patients under anesthesia are often "awake" but the drugs prevent them from forming memories so they can't complain once the anesthesia wears off.
"Anesthesia" is a wider umbrella term than most people realize with many levels of sedation.
Under "general anesthesia", the patient is completely unconscious. They don't respond to any stimuli. In rare cases, some patients may have an adverse reaction and still retain some sensation, but that's very uncommon. My understanding is that we are certain that patients are actually unconscious (and not just unable to respond) because none of the other involuntary responses to trauma occur during surgery: elevated heart rate, etc. In short, you are simply not there for a while. This is what you get for most kinds of significant surgeries unless the surgery requires you to be awake (like brain surgery where they may need to ask you questions).
"Sedation" or "twilight sedation" is a lower level of anesthesia. You are somewhat conscious and can respond to commands from the doctor. But you are unable to form memories of what's happening and you're usually on something like fentanyl that makes you entirely OK with whatever it is they are doing to you. This is common for procedures like colonoscopies and endoscopies where the procedure is somewhat uncomfortable but where you aren't being cut open.
In general, anesthesiologists are trying to balance the goal of patient comfort against the risks of deeper levels of sedation.
More like very rarely (1-2 per 1000), very partially aware. I could not find anything saying that it was common, and it appears cases of actual awareness to the point of having pain / trauma are far rarer still. People who have this tend to have foggy memories or other concrete PTSD symptoms after the fact. It does not appear to be the norm.
I still think this experimentation is absolutely insane and I strongly object because there is no way to get feedback from the "patient" after the fact. Since we have no real idea of what is happening, I believe we should err on the side of caution. "But they could consent beforehand" is not morally acceptable for intrinsically inhumane actions that take away fundamental human rights and dignity. So if you think this is possibly inhumane / potentially torture, it is an irrelevant point since true consent would be impossible.
That's how twilight anesthesia works. That's the kind you get when having something like wisdom tooth removal or an endoscopy. They want you to be responsive to instructions but completely relaxed and unable to form memories of the event.
It's still an open debate whether the seat of consciousness (or even simpler, perception) is the brain.
see e.g. Wahbeh, H., Radin, D., Cannard, C., & Delorme, A. (2022). What if consciousness is not an emergent property of the brain? Observational and empirical challenges to materialistic models. Frontiers in psychology, 13, 955594. https://doi.org/10.3389/fpsyg.2022.955594
Same for memory, which is "needed" as well for your question to make sense. The more current theories assume memories are stored not only in the brain, but throughout the body.
see e.g. Repetto, C., & Riva, G. (2023). The neuroscience of body memory: Recent findings and conceptual advances. EXCLI journal, 22, 191–206. https://doi.org/10.17179/excli2023-5877
Ok, I only skimmed the paper but it seems like all of the "non-local phenomena" in support of their theory are basically psychic powers. Not exactly strong evidence.
You're free to stop there. We can also turn it around, and I can ask you for any paper that details the theory of why the brain should be the location of consciousness.
I only gave one example and Wikipedia to start with. There's a lot of material out there if you're (rightfully) skeptical of that one paper. I don't even know what you're refering to as "their theory", as the way I read it, they're basically documenting various co-existing theories, and the authors don't disclose which one they find the most likely. I also don't see it as necessary for science to pick one; it's all about theories. I prefer documentation of all possible theories, and see no reason to dismiss one over the other unless they're disproven. I pointed to that paper, because any paper that talks about alternative theories shows the point I was making: We don't know yet. The point was not to claim that they've managed to put together good or bad arguments.
We understand the fundamental laws of physics well enough to say there is not some mysterious soul influencing the brain. Just like we can say that the moon is not made from cheese.
> Modern physics, in other words, provides evidence for what philosophers call “causal closure of the physical”: physical events have purely physical causes (Loewer 1995, Papineau 1995), at least in the regime relevant to human life. Without dramatically upending our understanding of quantum field theory, there is no room for any new influences that could bear on the problem of consciousness.
> We understand the fundamental laws of physics well enough to say there is not some mysterious soul influencing the brain. Just like we can say that the moon is not made from cheese.
I don't see how this relates to the "seat of consciousness" (with)in a human body, or how the biological system works together to "form it". Or where thinking or memory storage or retrieval takes place. At least that was what I was talking about. You're talking about something else.
It is a theory that we think in the brain. As far as I understand it, and please prove me wrong, there are other, valid theories? It's unscientific to discard theories purely based on belief. You seem to be arguing from a certain belief, not from science.
The modern term for "soul" is "psyche".
Remember that the OP was asking: "How do you ensure that you aren’t torturing a brain that can’t see, hear or scream?" -- clearly refering to something... conscious?
> It is a theory that we think in the brain. As far as I understand it, and please prove me wrong, there are other, valid theories? It's unscientific to discard theories purely based on belief. You seem to be arguing from a certain belief, not from science.
The evidence that the brain is where thinking happens is overwhelming, the minor influence of the rest of the body notwithstanding. There are no other theories.
Sure. We can't even agree on a good definition for "consciousness", we certainly don't know _how_ it works. I don't think there's a lot of debate around that specific point.
I'll try and read the paper more carefully after work, but my quick read was: they posit that consciousness might not be localized in the brain because if it were, then how would people be able to perform telepathy / remote viewing / future foresight? I can't assert that their non-local hypothesis is wrong, but I can pretty confidently say that the evidence they're using to back it up is unscientific BS.
Agreed. I don’t consider what they present as “evidence”. But that doesn’t turn it into evidence against the theories either. There are other theories that explain “out of body experiences”. We just don’t know. There doesn’t seem to be convincing enough evidence to make the case for “the brain is where consciousness resides”, nor is there against it.
We know the brain is the seat of consciousness because damage to the brain damages consciousness. There is no other organ in the body where that's true. You can completely replace all other organs without changing consciousness.
You can always find a paper by a quack that posits the earth is flat, that doesn't mean there's serious debate.
Can you point me to a paper or other source that proves that the brain is the seat of consciousness? Or that disproves other theories?
I am familiar with the works of Oliver Sacks, Paul Broks, and others, who have spent their lives researching damage to brains and the potential consequences for the psyche. I agree that it sounds like damage to the brain can have big impact, but none of that research, as far as I am aware, proves or even tries to argue that the brain is the only component necessary for consciousness to exist.
I am not interested in beliefs in one theory over another. I am not even asking for probabilities. I am asking for a scientific approach, which is to detail all possible (potentially fringe) theories until they're proven wrong. Anything else is the business of religion.
Singer, J., & Damasio, A. (2025). The physiology of interoception and its adaptive role in consciousness. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 380(1939), 20240305. https://doi.org/10.1098/rstb.2024.0305
We think that organs can be replaced with little apparent change in consciousness (- this is an active research area, too, by the way). There is also research into how body tissues may form a part of what other theories place exclusively in the brain.
Aderinto, N., Olatunji, G., Kokori, E., Ogieuhi, I. J., Moradeyo, A., Woldehana, N. A., Lawal, Z. D., Adetunji, B., Assi, G., Nazar, M. W., & Adebayo, Y. A. (2025). A narrative review on the psychosocial domains of the impact of organ transplantation. Discover mental health, 5(1), 20. https://doi.org/10.1007/s44192-025-00148-y
> "Having its own enteric nervous system, sometimes referred to as the “second brain,” the gut is also an immune organ and has a large surface area interacting with gut microbiota. The gut has been shown to play an important role in many physiological processes, and may arguably do so as well in perception and cognition."
Boem F, Greslehner GP, Konsman JP and Chiu L (2024) Minding the gut: extending embodied cognition and perception to the gut complex. Front. Neurosci. 17:1172783. https://doi.org/10.3389/fnins.2023.1172783
Ok, I've actually read into the 3 articles you've suggested and none of them are making the argument you are making. I think you just title mined.
Article 1. is about how the brain interprets incoming signals from the body
Article 2. is about dealing with psychiatric needs, such as medication compliance and stress, which result from organ transplants.
And, as I addressed in another comment, Article 3. is a discussion about the impacts of gut microbiome on mood. It is not a discussion of "consciousness".
Three are a million case studies and studies on it. So much so that you'll find studies on the best ways to repair consciousness after traumatic brain injuries [1].
You can't find a single case study where someone's consciousness was notably altered due to bowel resection. Something that has happened all the time.
Where are the people losing or having alerted consciousness after having their stomachs stapled? Their perforated bowels resected? Their bowel cancer polyps removed?
The closest you'll find is soldiers suffering from, understandable, PTSD.
Also, I'd point out that the studies you referenced aren't suggesting your point. They are saying that the gut can affect our mood and cravings. But as anyone that's taken a powerful antibiotic can attest, that did not modify their consciousness even though it nuked a huge portion of their biome.
People also get fecal transplants, they don't share consciousness as a result.
Unless you want to define consciousness as an eternal soul that exists in rocks, then you'll find no support for the suggestion that it exists outside a brain.
You also need to explain why it is that traumatic brain injuries alter consciousness and memory. Why it is that we can observe physical changes in the brains of dementia patients.
If you're going full philosophy of science, are these alternative theories falsifiable in the first place? Much of this kind of argument turns into philosophy and metaphysics instead of empirical science.
Imagine what would happen if we transplanted a head, or full brain, and the consciousness self would still remain the same, like with other organ transplantation.
We'll see!
I am saying: we can guess, but we don't know. I am not saying it's likely. I just want to remain precise in what are theories. It is a theory that consciousness "lives" inside the physical brain, as much as it is one that it doesn't. It is physically possible that it exists energetically and moves and stays with "the larger chunk of body".
I believe to some extent that everything is conscious and that it's specifically our species' prized mental features that lessen it's level at least temporarily. purely esoterically the statement "a rock is more conscious than a human being" doesn't even seem too outrageous to me.
Every other part of the human body is understandable but the brain.
Reading the article and imagining its you, sheeeeesh. I really wonder how this passed ethical review. Yes the brain is an organ, and yes there’s probably consent and the body is officially proclaimed dead and this is near the best way to really extrapolate the empirical data prior to alive human trials.
But damn this article is a combination of words I did not want to read today nor imagine.
There is also the practice of not using anesthesia on infants when undergoing medical surgery.
Anesthesia is hard to do even on adults, harder on children, and very difficult on infants. Not accidentally killing one is quite hard.
So, for a long time we just didn't. I think some countries still don't, but can't remember.
The idea really gets back all the way to philosophy. If you can't remember if you were in pain, did you get hurt? And then you add in the medical problem itself, the duty to do no harm, the difficulties, etc. The conclusion was to just not use pain meds.
Brain does not have physical feelings, and with all other feelings cut off and not possible, even with consciousness it won’t be a horror scenario like in MetallicA’s “One”.
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1. As it turned out, I was so frightened in the lead-up to the surgery that they had to do general anesthesia on me because I was shaking too much for them to operate so I was unconscious for the whole thing.