[cluckindan]

Kappa-opioid receptor activation causes a person to feel intense dissociative dysphoria. Pretty much the opposite of why people use opioids.

[cbonanno]

I don’t think this is true.

Opioid use has been associated with numerous psychiatric symptoms, including dissociative symptoms.

https://corescholar.libraries.wright.edu/psychiatry/62/

[cluckindan]

That’s probably because many opioids are ligands of both mu and kappa receptors.

Menthol, for example, only activates the kappa receptor: accidentally overdosing on pure menthol felt to me like immediate doom was approaching and nothing would ever again be fine.

I don’t eat anything menthol-flavored any more. It seems like an operant conditioning agent masquerading as a flavor.