[robobro]

Saliva divinorum is inherently dysphoric due to its agonism of the kappa opiod receptor. For a different cheap legal drug that affects serotonin and the NMDA receptors like ibogaine does, there's always off label use of dextromethorphan (cough medicine)!

[panflute]

Again I'm a bit baffled as to what the unstated thought process is. Ibogain and Saliva divinorum share a short term dysphoric experience from kappa opioid receptor interference that might be an effective way to eliminate Trauma from earlier memories. Why use the more dangerous of the two and why avoid the experience if the experience is the intervention?

[Trasmatta]

DXM is also the active ingredient in the antidepressant Auvelity (combined with bupropion)

Lot of interesting studies and anecdotes on its efficacy as an antidepressant

[firebot]

A small dose of DXM boosts the effectiveness of Wellbutrin by 10x or so. It's not an antidepressant itself. It's a dissociative and cough suppressant.

[Trasmatta]

This is incorrect. DXM is the active ingredient in Auvelity. Bupropion is included because it inhibits the enzyme that breaks down DXM quickly. The bupropion boosts the effectiveness of DXM as the primary antidepressant, NOT the other way around like you're suggesting.

[tastyfreeze]

Really difficult to find a cough syrup with only high amounts of DXM and nothing else. All the brands changed their recipes in the late 90s.

[jrflowers]

They just sell DXM in softgels and tablets now

Edit: apparently that’s not true. There’s a brand of DXM-only syrup called Robocough now. What a ridiculous name for a Legitimate Cough Medicine

[LoganDark]

Isn't DXM terribly neurotoxic at those doses?