[WalterBright]

Smallpox was much less deadly to Europeans than the Indians. Indians fell like flies to European diseases.

Covid seems to have its mortality dramatically shrunk.

Our genomes are full of bits and pieces of ancient disease DNA. Our bodies are full of bugs that have evolved into peaceful coexistence. Some bugs even became part of us (mitochondria).

[Veserv]

> Smallpox was much less deadly to Europeans than the Indians. Indians fell like flies to European diseases.

That does not support your argument that there is a adaptive advantage for reduced deadliness. The fact that it was exceedingly deadly to non co-evolved hosts indicates it was not the disease that became less deadly, but that the co-evolved hosts developed better defenses.

> Our bodies are full of bugs that have evolved into peaceful coexistence.

That is a argument that there is a continuous adaptive advantage to reduced deadliness down to ~0%. Again, Rabies had and continues to have a nearly 100% fatality rate in co-evolved hosts for thousands of years. Smallpox had a 10-30% fatality rate. Any magical inherent adaptive advantage for reduced deadliness failed to materialize to continue pushing down their deadliness.

Or put another way, a disease can have a 30% mortality rate and still do a really bang-up job at propagation with limited adaptive pressure to reduce that further for thousands of years. Peaceful coexistence is more likely a artifact of the specific dynamic than any sort of meaningful fundamental advantage to reduced deadliness.

[WalterBright]

> it was exceedingly deadly to non co-evolved hosts indicates it was not the disease that became less deadly, but that the co-evolved hosts developed better defenses

That's a good argument, but it is not proof that there wasn't some adaptation of smallpox to Europeans. The immune systems of Europeans and Indians diverged 10,000 years ago.

> Rabies had and continues to have a nearly 100% fatality rate in co-evolved hosts for thousands of years.

I doubt that there were large enough epidemics of rabies to influence its evolution.

> Peaceful coexistence is more likely a artifact of the specific dynamic than any sort of meaningful fundamental advantage to reduced deadliness.

Killing your host does not help propagation of the disease. Causing your host to cough and sneeze is a great way to propagate.

[tyre]

Smallpox was incredibly deadly to Europeans, until they built up immunity through millions of people dying.