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by gus_massa
4959 days ago
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> modified ribosomes that can assemble polypeptides using non-standard aminoacids (presumably coded for using four-base codons) This prediction is a little too much. Theoretically it is possible to use a four-base codons, but I'm almost sure that it is extremely difficult to make all the changes in every part of the process. For example, to change the number of bases in a codon, you must change the number of bases in the reciprocal part of the tRNA. But the shape of the tRNA depends on the length, and it seems to be very difficult to change this without breaking the other functions. It's much easier just to change the meaning of some codons (there are 64, and only 20 codified aminoacid + a termination mark), and even the mitochondrias and some estrange living organism have small changes in the genetic code. |
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