Possibly with https://github.com/tjfontaine/node-libclang. I'm actually working on a node module that will automatically parse header files using libclang and make native dynamic libraries available with no configuration required on the end of the developer. It will eventually be part of https://github.com/olalonde/better-require if you're interested.
An didn't know about this, looks great. Would you be interested in helping me write an add-on for better-require? Anyways, I'll try it out and see how it works out.