[SquareWheel]

I've been tweaking my Sublime for 5 months or so, and this is how my config file looks so far.

    "color_scheme": "Packages/Color Scheme - Default/Monokai.tmTheme",
    "detect_indentation": false,
    "detect_slow_plugins": false,
    "font_size": 10,
    "highlight_line": true,
    "highlight_modified_tabs": true,
    "margin": 0,
    "move_to_limit_on_up_down": true,
    "remember_open_files": false,
    "shift_tab_unindent": true,
    "tab_completion": false,
    "tab_size": 4,
    "translate_tabs_to_spaces": false,
    "word_wrap": false

I'd suggest going through the default settings file to see what options there are to change. It's pretty darn configurable.

I'd also like to suggest the plugins Bracket Highlighter and Emmet (previously Zen Coding). I also use Package Manager, Sublime Linter, and FileDiffs as mentioned in the article.

[wldlyinaccurate]

This is just my opinion, but I think detect_indentation should always be turned on. The reason being that having mixed indentation in a file is worse than having the "wrong" indentation.

[SquareWheel]

I use tabs strictly in my projects, but often times I work on websites built by other people and there's a hodgepodge of 2 spaces, 4 spaces, and tabs. It's best to leave it as it is and get out as soon as possible.